Open AccessNegative Regulation of Myofibroblast Differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10)
Author(s) -
Eric S. White,
Rachelle G. Atrasz,
Biao Hu,
Sem H. Phan,
Vuk Stambolic,
Tak W. Mak,
Cory M. Hogaboam,
Kevin R. Flaherty,
Fernando J. Martínez,
Christopher D. Kontos,
Galen B. Toews
Publication year - 2006
Publication title -
american journal of respiratory and critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.272
H-Index - 374
eISSN - 1535-4970
pISSN - 1073-449X
DOI - 10.1164/rccm.200507-1058oc
Subject(s) - pten , tensin , myofibroblast , cancer research , biology , fibroblast , fibrosis , microbiology and biotechnology , pathology , medicine , pi3k/akt/mtor pathway , cell culture , signal transduction , genetics
Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF). Defining mechanisms of myofibroblast differentiation may be critical to the development of novel therapeutic agents.