Open AccessA review of COVID-19 vaccination and the reported cardiac manifestations
Author(s) -
Jamie Sin-Ying Ho,
ChingHui Sia,
Jinghao Nicholas Ngiam,
Poay Huan Loh,
Nicholas Chew,
William Kong,
Kian Keong Poh
Publication year - 2021
Publication title -
singapore medical journal/singapore medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 61
eISSN - 2737-5935
pISSN - 0037-5675
DOI - 10.11622/smedj.2021210
Subject(s) - medicine , vaccination , myocarditis , pericarditis , covid-19 , myocardial infarction , cardiomyopathy , adverse effect , intensive care medicine , pediatrics , cardiology , immunology , heart failure , disease , infectious disease (medical specialty)
In Singapore, 9.03 million doses of the mRNA COVID-19 vaccines by Pfizer-BioNTech and Moderna have been administered, and 4.46 million people are fully vaccinated. An additional 87,000 people have been vaccinated with vaccines in World Health Organization’s Emergency Use Listing. The aim of this review is to explore the reported cardiac adverse events associated with different types of COVID-19 vaccines. 42 studies that reported cardiac side effects after COVID-19 vaccination were included in this study. Reported COVID-19 vaccine-associated cardiac adverse events were mainly myocarditis and pericarditis, most commonly seen in adolescent and young adult male individuals after mRNA vaccination. Reports of other events such as acute myocardial infarction, arrhythmia and stress cardiomyopathy were rare. Outcomes of post-vaccine myocarditis and pericarditis were good. Given the good vaccine efficacy and the high number of cases of infection, hospitalisation and death that could potentially be prevented, COVID-19 vaccine remains of overall benefit, based on the current available data.