Open AccessAn Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement
Author(s) -
Cynthia Ménard,
Robert C. Susil,
Peter L. Choyke,
Jonathan Coleman,
Robert L. Grubb,
Ahmed M. Gharib,
Axel Krieger,
Peter Guion,
David Thomasson,
Karen Ullman,
Sandeep Gupta,
Virginia Espina,
Lance A. Liotta,
Emanuel Petricoin,
Gabor Fitchtinger,
Louis L. Whitcomb,
Ergin Atalar,
C. Norman Coleman,
Kevin Camphausen
Publication year - 2005
Publication title -
molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 60
eISSN - 1536-0121
pISSN - 1535-3508
DOI - 10.1162/15353500200504181
Subject(s) - magnetic resonance imaging , dynamic contrast , prostate cancer , molecular imaging , magnetic resonance spectroscopic imaging , biopsy , contrast (vision) , cancer , radiology , medicine , pathology , in vivo , computer science , biology , computer vision , microbiology and biotechnology
The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patients with prostate cancer.