Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice | Zendy

Steven Warach | Zendy; Adrienne N. Dula | Zendy; Truman J. Milling | Zendy; Samantha Miller | Zendy; Leigh Allen | Zendy; Nathan D. Zuck | Zendy; Collin Miller | Zendy; Christine Jesser | Zendy; Lotika R. Misra | Zendy; Jefferson T. Miley | Zendy; Manzure Mawla | Zendy; Ming-Chieh Ding | Zendy; John Bertelson | Zendy; Annie Y. Tsui | Zendy; John R. Jefferson | Zendy; Holly M. Davison | Zendy; Darshan N. Shah | Zendy; Kent Ellington | Zendy; Matthew M. Padrick | Zendy; Alan S. Nova | Zendy; Vivek R. Krishna | Zendy; Lisa A Davis | Zendy; David Paydarfar | Zendy

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Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice

Author(s) -

Steven Warach,

Adrienne N. Dula,

Truman J. Milling,

Samantha Miller,

Leigh Allen,

Nathan D. Zuck,

Collin Miller,

Christine Jesser,

Lotika R. Misra,

Jefferson T. Miley,

Manzure Mawla,

Ming-Chieh Ding,

John Bertelson,

Annie Y. Tsui,

John R. Jefferson,

Holly M. Davison,

Darshan N. Shah,

Kent Ellington,

Matthew M. Padrick,

Alan S. Nova,

Vivek R. Krishna,

Lisa A Davis,

David Paydarfar

Publication year - 2022

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.122.038950

Subject(s) - tenecteplase , medicine , odds ratio , fibrinolytic agent , odds , stroke (engine) , thrombolysis , tissue plasminogen activator , emergency medicine , myocardial infarction , logistic regression , mechanical engineering , engineering

A 10-hospital regional network transitioned to tenecteplase as the standard of care stroke thrombolytic in September 2019 because of potential workflow advantages and reported noninferior clinical outcomes relative to alteplase in meta-analyses of randomized trials. We assessed whether tenecteplase use in routine clinical practice reduced thrombolytic workflow times with noninferior clinical outcomes.

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