Open AccessCausal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease
Author(s) -
Junfeng Liu,
Loes C.A. Rutten-Jacobs,
Ming Liu,
Hugh S. Markus,
Matthew Traylor
Publication year - 2018
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.117.020536
Subject(s) - mendelian randomization , medicine , hyperintensity , lacunar stroke , odds ratio , intracerebral hemorrhage , type 2 diabetes , stroke (engine) , type 2 diabetes mellitus , fractional anisotropy , diabetes mellitus , white matter , gastroenterology , magnetic resonance imaging , endocrinology , genotype , radiology , genetics , genetic variants , mechanical engineering , ischemic stroke , ischemia , engineering , gene , subarachnoid hemorrhage , biology
The relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin resistance on CSVD using Mendelian randomization.