Open AccessDiverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation
Author(s) -
Sung Ji Ahn,
Josef Anrather,
Nozomi Nishimura,
Chris B. Schaffer
Publication year - 2018
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.117.020461
Subject(s) - microglia , medicine , cx3cr1 , inflammation , lesion , pathology , neuroscience , immunology , chemokine , biology , chemokine receptor
Cerebral microbleeds are linked to cognitive decline, but it remains unclear how they impair neuronal function. Infarction is not typically observed near microbleeds, suggesting more subtle mechanisms, such as inflammation, may play a role. Because of their small size and largely asymptomatic nature, real-time detection and study of spontaneous cerebral microbleeds in humans and animal models are difficult.