Relation Between Leisure Time, Commuting, and Occupational Physical Activity With Blood Pressure in 125 402 Adults: The Lifelines Cohort

Background Whether all domains of daily‐life moderate‐to‐vigorous physical activity ( MVPA ) are associated with lower blood pressure ( BP ) and how this association depends on age and body mass index remains unclear. Methods and Results In the population‐based Lifelines cohort (N=125 402), MVPA was assessed by the Short Questionnaire to Assess Health‐Enhancing Physical Activity, a validated questionnaire in different domains such as commuting, leisure‐time, and occupational PA . BP was assessed using the last 3 of 10 measurements after 10 minutes’ rest in the supine position. Hypertension was defined as systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg and/or use of antihypertensives. In regression analysis, higher commuting and leisure‐time but not occupational MVPA related to lower BP and lower hypertension risk. Commuting‐and‐leisure‐time MVPA was associated with BP in a dose‐dependent manner. β Coefficients (95% CI ) from linear regression analyses were −1.64 (−2.03 to −1.24), −2.29 (−2.68 to −1.90), and finally −2.90 (−3.29 to −2.50) mm Hg systolic BP for the low, middle, and highest tertile of MVPA compared with “No MVPA ” as the reference group after adjusting for age, sex, education, smoking and alcohol use. Further adjustment for body mass index attenuated the associations by 30% to 50%, but more MVPA remained significantly associated with lower BP and lower risk of hypertension. This association was age dependent. β Coefficients (95% CI ) for the highest tertiles of commuting‐and‐leisure‐time MVPA were −1.67 (−2.20 to −1.15), −3.39 (−3.94 to −2.82) and −4.64 (−6.15 to −3.14) mm Hg systolic BP in adults <40, 40 to 60, and >60 years, respectively. Conclusions Higher commuting and leisure‐time but not occupational MVPA were significantly associated with lower BP and lower hypertension risk at all ages, but these associations were stronger in older adults.