Open AccessAngina Hospitalization Rates in Women With Signs and Symptoms of Ischemia But no Obstructive Coronary Artery Disease: A Report from the WISE (Women's Ischemia Syndrome Evaluation) Study
Author(s) -
Aldiwani Haider,
Zaya Melody,
Suppogu Nissi,
Quesada Odayme,
Johnson B. Delia,
Mehta Puja K.,
Shufelt Chrisandra,
Petersen John,
Azarbal Babak,
Samuels Bruce,
Anderson R. David,
Shaw Leslee J.,
Kar Saibal,
Handberg Eileen,
Kelsey Sheryl F.,
Pepine Carl J.,
Bairey Merz C. Noel
Publication year - 2020
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.119.013168
Subject(s) - medicine , coronary artery disease , cardiology , angina , hazard ratio , dyslipidemia , myocardial infarction , unstable angina , univariate analysis , proportional hazards model , ischemia , disease , multivariate analysis , confidence interval
Background Recurrent hospitalization is prevalent in women with signs and symptoms of ischemia and no obstructive coronary artery disease. We hypothesized that rates of angina hospitalization might have changed over time, given advances in diagnostic and therapeutic approaches. Methods and Results We evaluated 551 women enrolled in the WISE (Women's Ischemia Syndrome Evaluation) study with no obstructive coronary artery disease (CAD) for a follow‐up period of 9.1 years. We analyzed angina hospitalization rates using the Kaplan‐Meier method. Univariate analysis and multivariable Cox proportional hazard models were developed for prediction of angina hospitalization in women with signs and symptoms of angina and no CAD. A total of 223 women had nonobstructive CAD (>20–50%