Open AccessCoffee Consumption and Risk of Atrial Fibrillation in the Physicians’ Health Study
Author(s) -
Bodar Vijaykumar,
Chen Jiaying,
Gaziano J. Michael,
Albert Christine,
Djoussé Luc
Publication year - 2019
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.118.011346
Subject(s) - medicine , hazard ratio , atrial fibrillation , prospective cohort study , proportional hazards model , confidence interval , incidence (geometry) , lower risk , physics , optics
Background Although coffee consumption is often reported as a trigger for atrial fibrillation ( AF ) among patients with paroxysmal AF , prospective studies on the relation of coffee consumption with AF risk have been inconsistent. Hence, we sought to assess the association between coffee consumption and risk of AF in men. Methods and Results We prospectively studied men who participated in the Physicians’ Health Study (N=18 960). Coffee consumption was assessed through self‐reported food frequency questionnaires. The incidence of AF was assessed through annual questionnaires and validated through review of medical records in a subsample. Cox proportional hazard models were used to calculate hazard ratios and 95% CI s of AF . The average age was 66.1 years. A total of 2098 new cases of AF occurred during a mean follow‐up of 9 years. Hazard ratios (95% CI ) of AF were 1.0 (reference), 0.85 (0.71‐1.02), 1.07 (0.88‐1.30), 0.93 (0.74‐1.17), 0.85 (0.74‐0.98), 0.86 (0.76‐0.97), and 0.96 (0.80‐1.14) for coffee consumption of rarely/never, ≤1 cup/week, 2 to 4 cups/week, 5 to 6 cups/week, 1 cup/day, 2 to 3 cups/day, and 4+ cups/day, respectively; adjusting for age, smoking, alcohol intake, and exercise ( P for nonlinear trend=0.01). In a secondary analysis the multivariable adjusted hazard ratio (95% CI ) of AF per standard deviation (149‐mg) change in caffeine intake was 0.97 (0.92‐1.02). Conclusions Our data suggest a lower risk of AF among men who reported coffee consumption of 1 to 3 cups/day.