Open AccessUtility of Complementary Magnetic Resonance Plaque Imaging and Contrast‐Enhanced Ultrasound to Detect Carotid Vulnerable Plaques
Author(s) -
Motoyama Rie,
Saito Kozue,
Tonomura Shuichi,
IshibashiUeda Hatsue,
Yamagami Hiroshi,
Kataoka Hiroharu,
Morita Yoshiaki,
Uchihara Yuto,
Iihara Koji,
Takahashi Jun C.,
Sugie Kazuma,
Toyoda Kazunori,
Nagatsuka Kazuyuki
Publication year - 2019
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.118.011302
Subject(s) - medicine , magnetic resonance imaging , contrast enhanced ultrasound , radiology , carotid endarterectomy , stenosis , ultrasound , endarterectomy , neovascularization , angiogenesis
Background We aimed to improve the assessment quality of plaque vulnerability with combined use of magnetic resonance imaging and contrast‐enhanced ultrasound ( CEUS ). Methods and Results We prospectively enrolled 71 patients with internal carotid artery stenosis who underwent carotid endarterectomy and performed preoperative CEUS and magnetic resonance plaque imaging. We distinguished high–signal‐intensity plaques ( HIP s) and non‐ HIP s based on magnetization‐prepared rapid acquisition with gradient echo images. We graded them according to the CEUS contrast effect and compared the CEUS images with the carotid endarterectomy specimens. Among the 70 plaques, except 1 carotid endarterectomy tissue sample failure, 59 were classified as HIP s (43 symptomatic) and 11 were classified as non‐ HIP s (5 symptomatic). Although the magnetization‐prepared rapid acquisition with gradient echo findings alone had no significant correlation with symptoms ( P =0.07), concomitant use of magnetization‐prepared rapid acquisition with gradient echo and CEUS findings did show a significant correlation ( P <0.0001). CEUS showed that all 5 symptomatic non‐ HIP s had a high‐contrast effect. These 5 plaques were histopathologically confirmed as vulnerable, with extensive neovascularization but only a small amount of intraplaque hemorrhage. Conclusions Complementary use of magnetic resonance imaging and CEUS to detect intraplaque hemorrhage and neovascularization in plaques can be useful for evaluating plaque vulnerability, consistent with the destabilization process associated with neovessel formation and subsequent intraplaque hemorrhage.