Open AccessInteraction of Left Ventricular Size and Sex on Outcome of Cardiac Resynchronization Therapy Among Patients With a Narrow QRS Duration in the Echo CRT Trial
Author(s) -
Varma Niraj,
Sogaard Peter,
Bax Jeroen J.,
Abraham William T.,
Borer Jeffrey S.,
Dickstein Kenneth,
Singh Jagmeet P.,
Gras Daniel,
Holzmeister Johannes,
Brugada Josep,
Ruschitzka Frank
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.118.009592
Subject(s) - medicine , cardiac resynchronization therapy , hazard ratio , cardiology , heart failure , qrs complex , quartile , confidence interval , ejection fraction , ventricular dyssynchrony , ventricular remodeling
Longer QRS duration (QRSd) improves, but increased left ventricular (LV) end-diastolic volume (LVEDV) reduces, efficacy of cardiac resynchronization therapy (CRT). QRSd/LVEDV ratios differ between sexes. We hypothesized that in the EchoCRT (Echocardiography Guided Cardiac Resynchronization Therapy) trial enrolling patients with heart failure with QRSd <130 ms, those with larger LVEDV would deteriorate but those with the highest QRSd/LVEDV would improve with CRT.