Open AccessOrthostatic Hypotension and Risk of Clinical and Subclinical Cardiovascular Disease in Middle‐Aged Adults
Author(s) -
Juraschek Stephen P.,
Daya Natalie,
Appel Lawrence J.,
Miller Edgar R.,
McEvoy John William,
Matsushita Kunihiro,
Ballantyne Christie M.,
Selvin Elizabeth
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.118.008884
Subject(s) - medicine , cardiology , orthostatic vital signs , heart failure , myocardial infarction , hazard ratio , stroke (engine) , blood pressure , subclinical infection , natriuretic peptide , confidence interval , mechanical engineering , engineering
Background Although orthostatic hypotension ( OH ) is a well‐recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease ( CVD ) risk is controversial. Methods and Results Participants with OH , defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987–1989) within 2 minutes of standing. All participants were followed up for the development of myocardial infarction, heart failure, stroke, fatal coronary heart disease ( CHD ), any CHD (combination of silent, nonfatal, and fatal CHD or cardiac procedures), and all‐cause mortality. Participants were assessed for carotid intimal thickness and plaque during the first visit. Detectable high‐sensitivity troponin T (≥5 ng/L) and elevated NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide; ≥100 pg/mL) were determined in blood collected during the second visit (1990–1992). All associations were adjusted for known CVD risk factors. In 9139 participants (57% women; 23% black; mean age, 54±5.7 years), 3% had OH . During follow‐up (median, 26 years), OH was associated with myocardial infarction (hazard ratio [ HR ], 1.88; 95% confidence interval [ CI ], 1.44–2.46), congestive heart failure ( HR , 1.65; 95% CI , 1.34–2.04), stroke ( HR , 1.83; 95% CI , 1.35–2.48), fatal CHD ( HR , 2.77; 95% CI , 1.93–3.98), any CHD ( HR , 2.00; 95% CI , 1.64–2.44), and all‐cause mortality ( HR , 1.68; 95% CI , 1.45–1.95). OH was also associated with carotid intimal thickness (β, 0.05 mm; 95% CI , 0.04–0.07 mm), carotid plaque (odds ratio, 1.51; 95% CI , 1.18–1.93), detectable high‐sensitivity troponin T (odds ratio, 1.49; 95% CI , 1.16–1.93), and elevated NT ‐pro BNP (odds ratio, 1.92; 95% CI , 1.48–2.49). Conclusions OH identified in community‐dwelling middle‐aged adults was associated with future CVD events and subclinical CVD . Further research is necessary to establish a causal role for OH in the pathogenesis of CVD .