Open AccessEffect of Vegan Fecal Microbiota Transplantation on Carnitine‐ and Choline‐Derived Trimethylamine‐N‐Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome
Author(s) -
Smits Loek P.,
Kootte Ruud S.,
Levin Evgeni,
Prodan Andrei,
Fuentes Susana,
Zoetendal Erwin G.,
Wang Zeneng,
Levison Bruce S.,
Cleophas Maartje C. P.,
Kemper E. Marleen,
DallingaThie Geesje M.,
Groen Albert K.,
Joosten Leo A. B.,
Netea Mihai G.,
Stroes Erik S. G.,
Vos Willem M.,
Hazen Stanley L.,
Nieuwdorp Max
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.008342
Subject(s) - trimethylamine n oxide , transplantation , gut flora , medicine , metabolic syndrome , choline , endocrinology , gastroenterology , biology , immunology , biochemistry , trimethylamine , diabetes mellitus
Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan diet was associated with decreased plasma TMAO levels and nearly absent TMAO production on carnitine challenge.