English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background   ECG  global electrical heterogeneity ( GEH ) is associated with sudden cardiac death. We hypothesized that a genome‐wide association study would identify genetic loci related to  GEH .    Methods and Results  We tested genotyped and imputed variants in black (N=3057) and white (N=10 769) participants in the ARIC (Atherosclerosis Risk in Communities) study and CHS (Cardiovascular Health Study).  GEH  ( QRS ‐T angle, sum absolute  QRST  integral, spatial ventricular gradient magnitude, elevation, azimuth) was measured on 12‐lead  ECG s. Linear regression models were constructed with each  GEH  variable as an outcome, adjusted for age, sex, height, body mass index, study site, and principal components to account for ancestry.  GWAS  identified 10 loci that showed genome‐wide significant association with  GEH  in whites or joint ancestry. The strongest signal (rs7301677, near   TBX 3 ) was associated with  QRS ‐T angle (white standardized β+0.16 [95%  CI  0.13–0.19];  P =1.5×10 −26 ), spatial ventricular gradient elevation (+0.11 [0.08–0.14];  P =2.1×10 −12 ), and spatial ventricular gradient magnitude (−0.12 [95%  CI  −0.15 to −0.09];  P =5.9×10 −15 ). Altogether,  GEH ‐ SNP s explained 1.1% to 1.6% of  GEH  variance. Loci on chromosomes 4 (near   HMCN 2 ), 5 (  IGF 1R ), 11 (11p11.2 region cluster), and 7 (near   ACTB  ) are novel  ECG  phenotype‐associated loci. Several loci significantly associated with gene expression in the left ventricle (  HMCN 2  locus—with   HMCN 2 ;   IGF 1R  locus—with   IGF 1R ), and atria (  RP 11‐481J2.2  locus—with expression of a long non‐coding  RNA  and   NDRG 4 ).    Conclusions  We identified 10 genetic loci associated with  ECG GEH . Replication of  GEH GWAS  findings in independent cohorts is warranted. Further studies of  GEH ‐loci may uncover mechanisms of arrhythmogenic remodeling in response to cardiovascular risk factors.

journal of the american heart association

Genome‐Wide Associations of Global Electrical Heterogeneity  ECG  Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study)