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Background  Atherosclerotic cardiovascular disease ( ASCVD ) and cancer are among the leading causes of economic burden, morbidity, and mortality in the United States. We aimed to quantify the overall impact of cardiovascular modifiable risk factor ( CRF ) profile on healthcare expenditures among those with and without  ASCVD  and/or cancer.    Methods and Results  The 2012–2013 Medical Expenditure Panel Survey, a nationally representative adult sample (≥40 years), was utilized for the study. Variables included  ASCVD ,  CRF  (hypertension, diabetes mellitus, hypercholesterolemia, smoking, physical activity and/or obesity), and cancer (all). Two‐part econometric models analyzed cost data. Medical Expenditure Panel Survey participants (n=27 275, 59±9 years, 52% female) were studied and 14% had cancer, translating to 25.6 million  US  adults over 40 years of age. A higher prevalence of  ASCVD  was noted in those with versus without cancer (25% versus 14%). Absence of  ASCVD  and a more favorable  CRF  profile were associated with significantly lower expenditures across the spectrum of cancer diagnosis. Among cancer patients, the adjusted mean annual cost for those with and without  ASCVD  were $10 852 (95% confidence interval [8917, 12 788]) and $6436 (95% confidence interval [5531, 7342]). Among cancer patients without  ASCVD , adjusted annual healthcare expenditures among those with optimal versus poor  CRF  profile were $4782 and $7256.    Conclusions  In a nationally representative  US  adult population, absence of  ASCVD  and a favorable  CRF  profile were associated with significantly lower medical expenditure among cancer patients. This provides estimates to continue better cardiovascular management and prevention practices, while contextualizing the burden of cancer.

journal of the american heart association

Favorable Modifiable Cardiovascular Risk Profile Is Associated With Lower Healthcare Costs Among Cancer Patients: The 2012–2013 Medical Expenditure Panel Survey