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Background  The American Heart Association Mission: Lifeline STEMI ( ST ‐segment–elevation myocardial infarction) Systems Accelerator program, conducted in 16 regions across the United States to improve key care processes, resulted in more patients being treated within national guideline goals (time from first medical contact to device: <90 minutes for direct presenters to hospitals capable of performing percutaneous coronary intervention; <120 minutes for transfers). We examined whether the effort reduced reperfusion disparities in the proportions of female versus male and black versus white patients.    Methods and Results  In total, 23 809 patients (29.3% female, 82.3% white, and 10.7% black) presented with acute STEMI between July 2012 and March 2014. Change in the proportion of patients treated within guideline goals was compared between sex and race subgroups for patients presenting directly to hospitals capable of performing percutaneous coronary intervention (n=18 267) and patients requiring transfer (n=5542). The intervention was associated with an increase in the proportion of men treated within guideline goals that presented directly (58.7–62.1%,  P =0.01) or were transferred (43.3–50.7%,  P <0.01). An increase was also seen among white patients who presented directly (57.7–59.9%,  P =0.02) or were transferred (43.9–48.8%,  P <0.01). There was no change in the proportion of female or black patients treated within guideline goals, including both those presenting directly and transferred.    Conclusion  The  STEMI  Systems Accelerator project was associated with an increase in the proportion of patients meeting guideline reperfusion targets for male and white patients but not for female or black patients. Efforts to organize systems of  STEMI  care should implement additional processes targeting barriers to timely reperfusion among female and black patients.

Impact of Regional Systems of Care on Disparities in Care Among Female and Black Patients Presenting With ST ‐Segment–Elevation Myocardial Infarction