Open AccessCombination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial
Author(s) -
MacDonald Thomas M.,
Williams Bryan,
Webb David J.,
Morant Steve,
Caulfield Mark,
Cruickshank J. Kennedy,
Ford Ian,
Sever Peter,
Mackenzie Isla S.,
Padmanabhan Sandosh,
McCann Gerald P.,
Salsbury Jackie,
McInnes Gordon,
Brown Morris J.
Publication year - 2017
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.006986
Subject(s) - medicine , hydrochlorothiazide , tolerability , losartan , blood pressure , combination therapy , randomized controlled trial , urology , doxazosin , thiazide , diastole , adverse effect , cardiology , angiotensin ii
Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches.