Open AccessHigh‐Density Lipoprotein Cholesterol Concentration and Acute Kidney Injury After Cardiac Surgery
Author(s) -
Smith Loren E.,
Smith Derek K.,
Blume Jeffrey D.,
Linton MacRae F.,
Billings Frederic T.
Publication year - 2017
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.006975
Subject(s) - medicine , atorvastatin , perioperative , statin , acute kidney injury , creatinine , cholesterol , renal function , cardiac surgery , confounding , cardiology , surgery , gastroenterology
Acute kidney injury (AKI) after cardiac surgery is associated with increased short- and long-term mortality. Inflammation, oxidative stress, and endothelial dysfunction and damage play important roles in the development of AKI. High-density lipoproteins (HDLs) have anti-inflammatory and antioxidant properties and improve endothelial function and repair. Statins enhance HDL's anti-inflammatory and antioxidant capacities. We hypothesized that a higher preoperative HDL cholesterol concentration is associated with decreased AKI after cardiac surgery and that perioperative statin exposure potentiates this association.