Open AccessInterrelationships Among Flow‐Mediated Vasodilation, Nitroglycerine‐Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors
Author(s) -
Maruhashi Tatsuya,
Iwamoto Yumiko,
Kajikawa Masato,
Oda Nozomu,
Kishimoto Shinji,
Matsui Shogo,
Hashimoto Haruki,
Aibara Yoshiki,
Yusoff Farina Mohamad,
Hidaka Takayuki,
Kihara Yasuki,
Chayama Kazuaki,
Noma Kensuke,
Nakashima Ayumu,
Goto Chikara,
Hida Eisuke,
Higashi Yukihito
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.006797
Subject(s) - medicine , brachial artery , vasodilation , cardiology , reactive hyperemia , endothelium , blood pressure
Background Flow‐mediated vasodilation ( FMD ) of the brachial artery has been used for the assessment of endothelial function. Considering the mechanism underlying the vasodilatory response of the brachial artery to reactive hyperemia, hyperemic shear stress ( HSS ), a stimulus for FMD ; nitroglycerine‐induced vasodilation ( NID ), an index of endothelium‐independent vasodilation; and baseline brachial artery diameter ( BAD ) are also involved in vasodilatory response. The purpose of this study was to investigate the interrelationships among FMD , HSS , NID , baseline BAD , and cardiovascular risk factors. Methods and Results We measured FMD , HSS , NID , and baseline BAD simultaneously in 1033 participants (633 men and 400 women; mean age: 58.6±17.0 years). Framingham risk score was negatively correlated with FMD , HSS, and NID and was positively correlated with baseline BAD . HSS and NID were positively correlated with FMD , and baseline BAD was negatively correlated with FMD . In participants with normal NID , FMD was correlated with HSS , NID , and baseline BAD , all of which were independent variables of FMD in multivariate analysis. In participants with impaired NID , FMD was correlated with NID and baseline BAD , both of which were independent variables of FMD in multivariate analysis, but there was no association between FMD and HSS . Conclusions NID and baseline BAD were independent variables of FMD regardless of the status of endothelium‐independent vasodilation, whereas there was a significant association between FMD and HSS in participants with normal NID but not in those with impaired NID . The influence of HSS on FMD seems to be dependent on the status of endothelium‐independent vasodilation.