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Background  The aim of our study was to evaluate the relationship of pulse pressure ( PP ), a raw index of arterial stiffness, with noninvasively determined coronary flow reserve ( CFR ) and its components, in patients with angiographically normal epicardial coronary arteries.    Methods and Results  The study population included 398 patients without angiographic evidence of coronary stenosis, who underwent high‐dose dipyridamole stress echocardiography with transthoracic‐derived  CFR  evaluation on the left anterior descending artery.  CFR  was calculated as the ratio between high‐dose dipyridamole and resting coronary diastolic peak velocities. Patients were divided into 2 groups: the first group included the first and second  PP  tertiles (n=298,  PP  ≤60 mm Hg) and the second group included the highest  PP  tertile (n=100,  PP  >60 mm Hg). Mean blood pressure, systolic blood pressure (both  P <0.0001), age ( P <0.002), and left ventricular mass index ( P =0.013) were higher in the highest  PP  tertile, which also showed higher resting coronary flow velocity (31.6±9.6 cm/s versus 27.7±6.4 cm/s,  P <0.0001) and marginally lower  CFR  (2.5±0.6 versus 2.6±0.6,  P =0.044). Hyperemic coronary flow velocity did not differ between the 2 groups. By separate multiple linear regression analyses, after adjusting for sex, age, the highest systolic blood pressure tertile (≥140 mm Hg), left ventricular mass index, and cardiovascular risk factors, the highest  PP  tertile was associated with resting coronary flow velocity ( P =0.003) and only marginally with hyperemic coronary flow velocity ( P <0.02), whereas its association with  CFR  was not significant.    Conclusions  In patients without epicardial coronary artery stenosis, the highest  PP  tertile is associated with an increased coronary flow velocity at rest.

journal of the american heart association

Association Between Elevated Pulse Pressure and High Resting Coronary Blood Flow Velocity in Patients With Angiographically Normal Epicardial Coronary Arteries