Open AccessVitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability
Author(s) -
Marc Vila Cuenca,
Evelina Ferrantelli,
Elisa Meinster,
Stephan M. Pouw,
X. de Menezes,
Hans W. Niessen,
Robert H. J. Beelen,
Peter L. Hordijk,
Marc G. Vervloet
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.004294
Subject(s) - endothelial dysfunction , medicine , endothelium , vitamin d and neurology , heart failure , endocrinology , endothelial stem cell , human heart , gerontology , biology , biochemistry , in vitro
Background-—Dysfunctional endothelium may contribute to the development of cardiovascular complications in chronic kidney disease (CKD). Supplementation with active vitamin D has been proposed to have vasoprotective potential in CKD, not only by direct effects on the endothelium but also by an increment of a-Klotho. Here, we explored the capacity of the active vitamin D analogue paricalcitol to protect against uremia-induced endothelial damage and the extent to which this was dependent on increased a-Klotho concentrations.