Open AccessHemodynamic Profile of Patients With Heart Failure and Preserved Ejection Fraction Vary by Age
Author(s) -
Nanayakkara Shane,
Haykowsky Mark,
Mariani Justin,
Van Empel Vanessa,
Maeder Micha T.,
Vizi Donna,
Kaye David M.
Publication year - 2017
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.116.005434
Subject(s) - medicine , heart failure with preserved ejection fraction , cardiology , supine position , heart failure , pulmonary wedge pressure , ejection fraction , hemodynamics , pulmonary hypertension , blood pressure , arteriovenous oxygen difference , cohort , cardiac output , stroke volume
Background Patients with heart failure with preserved ejection fraction ( HFpEF ) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expression of HFpEF . We therefore sought to investigate the interaction between age and physiologic profile in patients with HFpEF . Methods and Results We assessed the hemodynamic and metabolic profile of 40 patients with HFpEF . Patients underwent right heart catheterization at rest and during supine cycle ergometry, and were segregated into 2 groups by the median age of the cohort. Older patients with HFpEF demonstrated reduced resting cardiac output (4.8±1.2 L/min versus 5.7±1.1 L/min). With exercise, older patients demonstrated a marked rise in arteriovenous oxygen content difference (10.8±1.8 versus 7.9±2.4 mL, P ≤0.001), driven by enhanced oxygen extraction. There was no significant difference in peak pulmonary capillary wedge pressure (30±7 mm Hg versus 27±6, P =0.135), including when indexed to workload (pulmonary capillary wedge pressure/W, 0.88 mm Hg/W versus 0.92; P =0.83). Conclusions Older patients with HFpEF display a different physiological phenotype compared with younger patients, with enhanced oxygen extraction and lower increment in cardiac output to increase oxygen consumption from rest to peak supine exercise. This finding highlights the importance in considering age when considering therapeutic options in patients with HFpEF .