Open AccessEffectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension: The PREVER‐Prevention Randomized Clinical Trial
Author(s) -
Fuchs Sandra Costa,
PolideFigueiredo Carlos E.,
Figueiredo Neto José A.,
Scala Luiz César N.,
Whelton Paul K.,
Mosele Francisca,
Mello Renato Bandeira,
VilelaMartin José F.,
Moreira Leila B.,
Chaves Hilton,
Mota Gomes Marco,
Sousa Marcos R.,
Silva Ricardo Pereira e,
Castro Iran,
Cesarino Evandro José,
Jardim Paulo Cesar,
Alves João Guilherme,
Steffens André Avelino,
Brandão Andréa Araujo,
ConsolimColombo Fernanda M.,
Alencastro Paulo Ricardo,
Neto Abrahão Afiune,
Nóbrega Antônio C.,
Franco Roberto Silva,
Sobral Filho Dario C.,
Bordig Alexandro,
Nobre Fernando,
Schlatter Rosane,
Gus Miguel,
Fuchs Felipe C.,
Berwanger Otávio,
Fuchs Flávio D.
Publication year - 2016
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.116.004248
Subject(s) - medicine , chlorthalidone , microalbuminuria , placebo , prehypertension , blood pressure , diuretic , randomized controlled trial , hazard ratio , incidence (geometry) , cumulative incidence , diabetes mellitus , endocrinology , confidence interval , cohort , physics , alternative medicine , pathology , optics
Prehypertension is associated with higher cardiovascular risk, target organ damage, and incidence of hypertension. The Prevention of Hypertension in Patients with PreHypertension (PREVER-Prevention) trial aimed to evaluate the efficacy and safety of a low-dose diuretic for the prevention of hypertension and end-organ damage.