Open AccessAldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure
Author(s) -
Pitts Reynaria,
Gunzburger Elise,
Ballantyne Christie M.,
Barter Philip J.,
Kallend David,
Leiter Lawrence A.,
Leitersdorf Eran,
Nicholls Stephen J.,
Shah Prediman K.,
Tardif JeanClaude,
Olsson Anders G.,
McMurray John J. V.,
Kittelson John,
Schwartz Gregory G.
Publication year - 2017
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.116.004119
Subject(s) - medicine , aldosterone , myocardial infarction , hazard ratio , cardiology , heart failure , acute coronary syndrome , unstable angina , clinical endpoint , proportional hazards model , confidence interval , randomized controlled trial
Aldosterone may have adverse effects in the myocardium and vasculature. Treatment with an aldosterone antagonist reduces cardiovascular risk in patients with acute myocardial infarction complicated by heart failure (HF) and left ventricular systolic dysfunction. However, most patients with acute coronary syndrome do not have advanced HF. Among such patients, it is unknown whether aldosterone predicts cardiovascular risk.