Open AccessImpact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome ( TRANSLATE ‐ ACS ) Study
Author(s) -
Jackson Larry R.,
Peterson Eric D.,
McCoy Lisa A.,
Ju Christine,
Zettler Marjorie,
Baker Brian A.,
Messenger John C.,
Faries Douglas E.,
Effron Mark B.,
Cohen David J.,
Wang Tracy Y.
Publication year - 2016
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.116.003824
Subject(s) - prasugrel , clopidogrel , medicine , mace , percutaneous coronary intervention , cardiology , myocardial infarction , hazard ratio , confidence interval
Proton pump inhibitors (PPIs) reduce gastrointestinal bleeding events but may alter clopidogrel metabolism. We sought to understand the comparative effectiveness and safety of prasugrel versus clopidogrel in the context of proton pump inhibitor (PPI) use.