Open AccessDietary α‐Linolenic Acid, Marine ω‐3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
Author(s) -
SalaVila Aleix,
GuaschFerré Marta,
Hu Frank B.,
SánchezTainta Ana,
Bulló Mònica,
SerraMir Mercè,
LópezSabater Carmen,
Sorlí Jose V.,
Arós Fernando,
Fiol Miquel,
Muñoz Miguel A.,
SerraMajem Luis,
Martínez J. Alfredo,
Corella Dolores,
Fitó Montserrat,
SalasSalvadó Jordi,
MartínezGonzález Miguel A.,
Estruch Ramón,
Ros Emilio
Publication year - 2016
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.115.002543
Subject(s) - medicine , polyunsaturated fatty acid , hazard ratio , proportional hazards model , population , linolenic acid , coronary artery disease , lower risk , fish oil , alpha linolenic acid , fatty acid , physiology , docosahexaenoic acid , food science , linoleic acid , environmental health , confidence interval , fish <actinopterygii> , biochemistry , biology , fishery
Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day).