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Background  To address the lack of knowledge regarding the long‐term risk of intracranial hemorrhage ( ICH ) after acute myocardial infarction ( AMI ), the aims of this study were to: (1) investigate the incidence, time trends, and predictors of  ICH  in a large population within 1 year of discharge after  AMI ; (2) investigate the comparative 1‐year risk of  ICH  in  AMI  patients and a reference group; and (3) study the impact of previous ischemic stroke on  ICH  risk in patients treated with various antithrombotic therapies.    Methods and Results  Data about patients whose first  AMI  occurred between 1998 and 2010 were collected from the Swedish Register of Information and Knowledge about Swedish Heart‐Intensive‐Care Admissions ( RIKS ‐ HIA ). Patients with an  ICH  after discharge were identified in the National Patient Register. Risk was compared against a matched reference population. Of 187 386 patients, 590 had an  ICH  within 1 year. The 1‐year cumulative incidence (0.35%) was approximately twice that of the reference group, and it did not change significantly over time. Advanced age, previous ischemic or hemorrhagic stroke, and reduced glomerular filtration rate were associated with increased  ICH  risk, whereas female sex was associated with a decreased risk. Previous ischemic stroke did not increase risk of  ICH  associated with single or dual antiplatelet therapy, but increased risk with anticoagulant therapy.    Conclusion  The 1‐year incidence of  ICH  after  AMI  remained stable, at ≈0.35%, over the study period. Advanced age, decreased renal function, and previous ischemic or hemorrhagic stroke are predictive of increased  ICH  risk.

Incidence, Time Trends, and Predictors of Intracranial Hemorrhage During Long‐Term Follow‐up After Acute Myocardial Infarction