Open AccessFeasibility and Accuracy of Cardiac Magnetic Resonance Imaging–Based Whole‐Heart Inverse Potential Mapping of Sinus Rhythm and Idiopathic Ventricular Foci
Author(s) -
Bhagirath Pranav,
Graaf Maurits,
Dongen Elise,
Hooge Jacques,
Driel Vincent,
Ramanna Hemanth,
Groot Natasja,
Götte Marco J. W.
Publication year - 2015
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.115.002222
Subject(s) - medicine , magnetic resonance imaging , intraclass correlation , sinus rhythm , cardiac magnetic resonance imaging , tomography , nuclear medicine , radiology , biomedical engineering , cardiology , atrial fibrillation , clinical psychology , psychometrics
Background Inverse potential mapping ( IPM ) noninvasively reconstructs cardiac surface potentials using body surface potentials. This requires a volume conductor model ( VCM ), usually constructed from computed tomography; however, computed tomography exposes the patient to harmful radiation and lacks information about tissue structure. Magnetic resonance imaging ( MRI ) is not associated with this limitation and might have advantages for mapping purposes. This feasibility study investigated a magnetic resonance imaging–based IPM approach. In addition, the impact of incorporating the lungs and their particular resistivity values was explored. Methods and Results Three volunteers and 8 patients with premature ventricular contractions scheduled for ablation underwent 65‐electrode body surface potential mapping. A VCM was created using magnetic resonance imaging. Cardiac surface potentials were estimated from body surface potentials and used to determine the origin of electrical activation. The IPM ‐defined origin of sinus rhythm corresponded well with the anatomic position of the sinus node, as described in the literature. In patients, the IPM ‐derived premature ventricular contraction focus was 3‐dimensionally located within 8.3±2.7 mm of the invasively determined focus using electroanatomic mapping. The impact of lungs on the IPM was investigated using homogeneous and inhomogeneous VCM s. The inhomogeneous VCM , incorporating lung‐specific conductivity, provided more accurate results compared with the homogeneous VCM (8.3±2.7 and 10.3±3.1 mm, respectively; P =0.043). The interobserver agreement was high for homogeneous (intraclass correlation coefficient 0.862, P =0.003) and inhomogeneous (intraclass correlation coefficient 0.812, P =0.004) VCMs . Conclusion Magnetic resonance imaging–based whole‐heart IPM enables accurate spatial localization of sinus rhythm and premature ventricular contractions comparable to electroanatomic mapping. An inhomogeneous VCM improved IPM accuracy.