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Background  Transient nonfocal neurological symptoms may serve as markers of cardiac dysfunction. We assessed whether serum N‐terminal pro–brain natriuretic peptide ( NT ‐pro BNP)  levels, a biomarker of cardiac disease, are increased in patients with transient ischemic attack  (TIA)  accompanied by nonfocal symptoms and in patients with attacks of nonfocal symptoms (transient neurological attack [ TNA] ).    Methods and Results  We included 15 patients with  TNA , 69 with  TIA  accompanied by nonfocal symptoms, 58 with large‐vessel  TIA , 32 with cardioembolic  TIA , and 46 age‐ and sex‐matched healthy control participants. Serum  NT ‐pro BNP  levels were determined within 1 week after the attack. We compared log‐transformed  NT ‐pro BNP  levels of patients with cardioembolic  TIA s and mixed or nonfocal  TNA s, with those of patients with noncardioembolic  TIA s as a reference group. Adjustments for age, sex, atrial fibrillation, and a history of nonischemic heart disease were made with a multiple linear regression model. Compared with large‐vessel  TIA  (mean 14.2 pmol/L), mean  NT ‐pro BNP  levels were significantly higher in patients with  TIA  accompanied by nonfocal symptoms (40.5 pmol/L,  P =0.049) and with cardioembolic  TIA  (123.5 pmol/L;  P =0.004) after adjustments for age, sex, atrial fibrillation, and a history of nonischemic heart disease. Patients with  TNA  also had higher mean  NT ‐pro BNP  levels (20.8 pmol/L,  P =0.38) than those with large‐vessel  TIA , but this difference was not statistically significant.    Conclusion   NT ‐pro BNP  levels are increased in patients with  TIA  accompanied by nonfocal symptoms.

N‐Terminal Pro–Brain Natriuretic Peptide (NT‐proBNP) Levels are Increased in Patients With Transient Ischemic Attack Accompanied by Nonfocal Symptoms