Open AccessKorean Atrial Fibrillation ( AF ) Network: Genetic Variants for AF Do Not Predict Ablation Success
Author(s) -
Choi EueKeun,
Park Jae Hyung,
Lee JiYoung,
Nam Chung Mo,
Hwang Min Ki,
Uhm JaeSun,
Joung Boyoung,
Ko YoungGuk,
Lee MoonHyoung,
Lubitz Steven A.,
Ellinor Patrick T.,
Pak HuiNam
Publication year - 2015
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.115.002046
Subject(s) - odds ratio , medicine , single nucleotide polymorphism , atrial fibrillation , catheter ablation , snp , cardiology , population , genetics , genotype , biology , gene , environmental health
Background Genomewide association studies have identified several loci associated with atrial fibrillation ( AF ) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms ( SNP s) at chromosomes 4q25 ( PITX 2 ), 16q22 ( ZFHX 3 ), and 1q21 ( KCNN 3 ) were associated with AF in a Korean population and whether these SNP s were associated with clinical outcomes after catheter ablation for AF . Methods and Results We determined the association between 4 SNP s and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF ) and 1068 age‐ and sex‐matched controls. The SNP s at the PITX 2 and ZFHX 3 loci, but not the KCNN 3 locus, were significantly associated with AF ( PITX 2 /rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P =1.32×10 −16 ; PITX 2 /rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P =2.20×10 −11 ; ZFHX 3 /rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P =3.75×10 −14 ; KCNN 3 /rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P =0.085). Among those patients who underwent catheter ablation for AF , none of the top AF ‐associated SNP s were associated with long‐term clinical recurrence of AF after catheter ablation. Conclusions SNP s at the PITX 2 and ZFHX 3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF ‐susceptibility SNP s predicted clinical recurrence after catheter ablation.