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Background  Mammalian SWItch/Sucrose NonFermentable ( SWI / SNF ) adenosine triphosphate ( ATP )‐dependent chromatin‐remodeling complexes play important roles in embryonic vascular development by modulating transcription of specific target genes. We sought to determine whether  SWI / SNF  complexes likewise impact postnatal physiological and pathological angiogenesis.    Methods and Results  Brahma‐related gene 1 ( BRG 1) and Brahma gene ( BRM)  are  ATP ases within mammalian  SWI / SNF  complexes and are essential for the complexes to function. Using mice with vascular‐specific mutations in  Brg1  or with a global mutation in  Brm , we employed 3 models to test the role of these  ATP ases in postnatal angiogenesis. We analyzed neonatal retinal angiogenesis, exercise‐induced angiogenesis in adult quadriceps muscles, and tumor angiogenesis in control and mutant animals. We found no evidence of defective angiogenesis in  Brg1  or  Brm  mutants using these 3 models.  Brg1/Brm  double mutants likewise show no evidence of vascular defects in the neonatal retina or tumor angiogenesis models. However, 100% of  Brg1/Brm ‐double mutants in which  Brg1  deletion is induced at postnatal day 3 (P3) die by P19 with hemorrhaging in the small intestine and heart.    Conclusions  Despite their important roles in embryonic vascular development,  SWI / SNF  chromatin‐remodeling complexes display a surprising lack of participation in the 3 models of postnatal angiogenesis we analyzed. However, these complexes are essential for maintaining vascular integrity in specific tissue beds before weaning. These findings highlight the temporal and spatial specificity of  SWI / SNF  activities in the vasculature and may indicate that other chromatin‐remodeling complexes play redundant or more essential roles during physiological and pathological postnatal vascular development.

journal of the american heart association

SWI / SNF  Chromatin‐Remodeling Enzymes Brahma‐Related Gene 1 ( BRG 1) and Brahma ( BRM ) Are Dispensable in Multiple Models of Postnatal Angiogenesis But Are Required for Vascular Integrity in Infant Mice