Open AccessComprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
Author(s) -
Vicente Jose,
Johannesen Lars,
Mason Jay W.,
Crumb William J.,
Pueyo Esther,
Stockbridge Norman,
Strauss David G.
Publication year - 2015
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.114.001615
Subject(s) - dofetilide , ranolazine , herg , quinidine , verapamil , pharmacology , long qt syndrome , sodium channel blocker , qt interval , sodium channel , medicine , potassium channel , calcium , chemistry , sodium , organic chemistry
Congenital long QT syndrome type 2 (abnormal hERG potassium channel) patients can develop flat, asymmetric, and notched T waves. Similar observations have been made with a limited number of hERG-blocking drugs. However, it is not known how additional calcium or late sodium block, that can decrease torsade risk, affects T wave morphology.