Open AccessAtaxia‐Telangiectasia Mutated Kinase: A Potential New Target for Suppressing Inflammation in Heart Failure?
Author(s) -
Kukreja Rakesh C.
Publication year - 2014
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.114.001591
Subject(s) - ataxia telangiectasia , dna repair , dna damage , medicine , cancer research , kinase , cell cycle , chek1 , dna pkcs , microbiology and biotechnology , cell cycle checkpoint , protein kinase a , biology , genetics , dna , cancer
Ataxia‐telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxia‐telangiectasia, plays an essential role in the maintenance of genome stability (reviewed in ref. [1][1]). ATM (a serine/threonine protein kinase) senses DNA double‐strand breaks and