Open AccessDark Chocolate Acutely Improves Walking Autonomy in Patients With Peripheral Artery Disease
Author(s) -
Loffredo Lorenzo,
Perri Ludovica,
Catasca Elisa,
Pignatelli Pasquale,
Brancorsini Monica,
Nocella Cristina,
De Falco Elena,
Bartimoccia Simona,
Frati Giacomo,
Carnevale Roberto,
Violi Francesco
Publication year - 2014
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.114.001072
Subject(s) - medicine , arterial disease , peripheral , disease , dark chocolate , cardiology , vascular disease , food science , chemistry
NOX-2, the catalytic subunit of NADPH oxidase, has a key role in the formation of reactive oxidant species and is implicated in impairing flow-mediated dilation (FMD). Dark chocolate exerts artery dilatation via down-regulating NOX2-mediated oxidative stress. The aim of this study was to investigate whether dark chocolate improves walking autonomy in peripheral artery disease (PAD) patients via an oxidative stress-mediated mechanism.