Open AccessAntifailure Therapy Including Spironolactone Improves Left Ventricular Energy Supply‐Demand Relations in Nonischemic Dilated Cardiomyopathy
Author(s) -
Bell Susan P.,
Adkisson Douglas W.,
Lawson Mark A.,
Wang Li,
Ooi Henry,
Sawyer Douglas B.,
Kronenberg Marvin W.
Publication year - 2014
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.114.000883
Subject(s) - medicine , spironolactone , cardiology , heart failure , ejection fraction , dilated cardiomyopathy , ventricular remodeling , cardiac resynchronization therapy , perfusion
Left ventricular (LV) energy supply-demand imbalance is postulated to cause "energy starvation" and contribute to heart failure (HF) in nonischemic dilated cardiomyopathy (NIDCM). Using cardiac magnetic resonance (CMR) and [(11)C] acetate positron emission tomography (PET), we evaluated LV perfusion and oxidative metabolism in NIDCM and the effects of spironolactone on LV supply-demand relations.