Open AccessMedial and Intimal Calcification in Chronic Kidney Disease: Stressing the Contributions
Author(s) -
Rogers Maximillian,
Goettsch Claudia,
Aikawa Elena
Publication year - 2013
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.113.000481
Subject(s) - medicine , kidney disease , diabetes mellitus , center of excellence , calcification , gerontology , endocrinology , political science , law
Cardiovascular calcification is a prominent feature of chronic inflammatory disorders that associate with significant morbidity and mortality. Vascular calcification is highly prevalent in patients with chronic kidney disease (CKD), a multifactorial disorder. CKD often results from hypertension and diabetes, and patients with CKD are among the highest-risk groups for cardiovascular events. Notably, CKD accelerates the development of atherosclerosis. Our group and others have demonstrated that CKD causes excessive vascular inflammation and calcification. 1 CKD is characterized