Open AccessThe Endothelium Abridges Insulin Resistance to Premature Aging
Author(s) -
Avogaro Angelo,
Kreutzenberg Saula Vigili,
Federici Massimo,
Fadini Gian Paolo
Publication year - 2013
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.113.000262
Subject(s) - medicine , insulin resistance , endothelium , insulin , cardiology , intensive care medicine
Although there are different mechanistic theories for aging,[1][1] endothelial dysfunction (ED) is a rather neglected player in the aging process. A maladaptive insulin/IGF-1-like signaling (IIS) has a remarkable importance in proaging mechanisms, and insulin has direct effects on ED.[2][2]