Open AccessRegular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial
Author(s) -
I. MacIntyre,
Emma Turtle,
Tariq E. Farrah,
Catriona Graham,
James W. Dear,
David J. Webb,
M. Jane A. McCallum,
Vanessa Melville,
Henry Fok,
Jame McCrae,
Ashish Anil Sule,
Thomas M. Caparrotta,
Nicholas S. Kirkby,
Jane A. Mitchell
Publication year - 2022
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.121.056015
Subject(s) - medicine , placebo , acetaminophen , blood pressure , ambulatory blood pressure , crossover study , ambulatory , anesthesia , morning , dosing , alternative medicine , pathology
Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (BP). Although observational studies suggest that acetaminophen may increase BP, clinical trials are lacking. We, therefore, studied the effects of regular acetaminophen dosing on BP in individuals with hypertension.