Open AccessHHIPL1 , a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis
Author(s) -
Dimitra Aravani,
George E. Morris,
Peter D. Jones,
Helena K. Tattersall,
Elisavet Karamanavi,
Michael Kaiser,
Renata B. Kostogrys,
Maryam Ghaderi Najafabadi,
Sarah Andrews,
Mintu Nath,
Shu Ye,
Emma J. Stringer,
Nilesh J. Samani,
Tom R. Webb
Publication year - 2019
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.119.041059
Subject(s) - hedgehog signaling pathway , hedgehog , gene knockdown , sonic hedgehog , biology , vascular smooth muscle , medicine , endocrinology , cancer research , signal transduction , microbiology and biotechnology , pathology , gene , genetics , smooth muscle
Genome-wide association studies have identified chromosome 14q32 as a locus for coronary artery disease. The disease-associated variants fall in a hitherto uncharacterized gene called HHIPL1 (hedgehog interacting protein-like 1), which encodes a sequence homolog of an antagonist of hedgehog signaling. The function of HHIPL1 and its role in atherosclerosis are unknown.