Open AccessBlood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase
Author(s) -
Oleksandra Prysyazhna,
Kathryn Wolhuter,
Christopher Switzer,
Célio X.C. Santos,
Xiaoping Yang,
Steven Lynham,
Ajay M. Shah,
Philip Eaton,
Joseph R. Burgoyne
Publication year - 2019
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.118.037398
Subject(s) - resveratrol , oxidative stress , antioxidant , pharmacology , biochemistry , reactive oxygen species , chemistry , medicine
The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the mechanisms of its therapeutic actions. The polyphenolic rings of resveratrol enable it to react with and detoxify otherwise injurious oxidants. Whilst the protective actions of resveratrol are commonly ascribed to its antioxidant activity, here we show that this is a misconception.