Open AccessAssessing the Causal Role of Body Mass Index on Cardiovascular Health in Young Adults
Author(s) -
Kaitlin H Wade,
Scott T Chiesa,
Alun D. Hughes,
Nish Chaturvedi,
Marietta Charakida,
Alicja Rapala,
Vivek Muthurangu,
Tauseef Khan,
Nick Finer,
Naveed Sattar,
Laura D Howe,
Abigail Fraser,
Debbie A Lawlor,
George Davey Smith,
John Deanfield,
Nicholas J. Timpson
Publication year - 2018
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.117.033278
Subject(s) - medicine , mendelian randomization , body mass index , cardiology , cardiovascular health , blood pressure , cohort , demography , genotype , disease , biochemistry , chemistry , sociology , genetic variants , gene
Body mass index (BMI) has been suggested to be causally related to cardiovascular health in mid-to-late life, but this has not been explored systematically at younger ages - nor with detailed cardiovascular phenotyping. Recall-by-Genotype (RbG) is an approach that enables the collection of precise phenotypic measures in smaller studies, whilst maintaining statistical power and ability for causal inference.