Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease | Zendy

Catherine Chinhchu Lai | Zendy; Bliss Nelsen | Zendy; Eduardo Frías-Anaya | Zendy; Helios Gallego-Gutiérrez | Zendy; Marco Orecchioni | Zendy; Victoria Herrera | Zendy; Elan Ortiz | Zendy; Hao Sun | Zendy; Omar A. Mesarwi | Zendy; Klaus Ley | Zendy; Brendan Gongol | Zendy; Miguel Alejandro LopezRamirez | Zendy

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Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease

Author(s) -

Catherine Chinhchu Lai,

Bliss Nelsen,

Eduardo Frías-Anaya,

Helios Gallego-Gutiérrez,

Marco Orecchioni,

Victoria Herrera,

Elan Ortiz,

Hao Sun,

Omar A. Mesarwi,

Klaus Ley,

Brendan Gongol,

Miguel Alejandro LopezRamirez

Publication year - 2022

Publication title -

circulation research

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.122.321129

Subject(s) - neuroinflammation , biology , microglia , endothelium , inflammation , pathogenesis , inflammasome , microbiology and biotechnology , pyrin domain , immunology , pathology , cancer research , medicine , genetics

Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1 ), CCM2 , and PDCD10 (CCM3 ). CCMs affect ≈1 out of 200 children and adults, and no pharmacologic therapy is available. CCM lesion count, size, and aggressiveness vary widely among patients of similar ages with the same mutation or even within members of the same family. However, what determines the transition from quiescent lesions into mature and active (aggressive) CCM lesions is unknown.

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