Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations | Zendy

Alexander J. Sparrow | Zendy; Kolja Sievert | Zendy; Suketu Patel | Zendy; YuFen Chang | Zendy; Connor N. Broyles | Zendy; Frances A. Brook | Zendy; Hugh Watkins | Zendy; Michael A. Geeves | Zendy; Charles Redwood | Zendy; Paul Robinson | Zendy; Matthew J. Daniels | Zendy

Open Access

Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations

Author(s) -

Alexander J. Sparrow,

Kolja Sievert,

Suketu Patel,

YuFen Chang,

Connor N. Broyles,

Frances A. Brook,

Hugh Watkins,

Michael A. Geeves,

Charles Redwood,

Paul Robinson,

Matthew J. Daniels

Publication year - 2019

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.118.314600

Subject(s) - myofilament , sarcomere , troponin i , medicine , troponin , actin , troponin c , troponin complex , cardiomyopathy , cardiology , myofibril , hypertrophic cardiomyopathy , troponin t , levosimendan , myocyte , heart failure , biophysics , chemistry , biology , microbiology and biotechnology , myocardial infarction

Subcellular Ca 2+ indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through myofilament Ca 2+ sensitivity. Here, we develop and characterize genetically encoded Ca 2+ indicators restricted to the myofilament to directly visualize Ca 2+ changes in the sarcomere.

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