Open AccessThe Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program
Author(s) -
Viktoria Kalna,
Youwen Yang,
Claire Peghaire,
Karen Frudd,
Rebecca Hannah,
Amit Shah,
Lourdes Osuna Almagro,
Joseph J. Boyle,
Berthold Göttgens,
Jorge Ferrer,
Anna M. Randi,
Graeme M. Birdsey
Publication year - 2019
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.118.313788
Subject(s) - enhancer , biology , enhancer rnas , transcription factor , microbiology and biotechnology , tmprss2 , chromatin immunoprecipitation , cancer research , gene expression , promoter , genetics , gene , medicine , infectious disease (medical specialty) , disease , covid-19
The ETS (E-26 transformation-specific) transcription factor ERG (ETS-related gene) is essential for endothelial homeostasis, driving expression of lineage genes and repressing proinflammatory genes. Loss of ERG expression is associated with diseases including atherosclerosis. ERG's homeostatic function is lineage-specific, because aberrant ERG expression in cancer is oncogenic. The molecular basis for ERG lineage-specific activity is unknown. Transcriptional regulation of lineage specificity is linked to enhancer clusters (super-enhancers).