Open AccessPak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response
Author(s) -
Pablo Binder,
Shunyao Wang,
Maria Radu,
Min Zin,
Lucy Collins,
Saba Khan,
Yatong Li,
Karolina Sekeres,
Neil Humphreys,
Eileithyia Swanton,
Adam J. Reid,
Fay Pu,
Delvac Oceandy,
Kaomei Guan,
Susanne Hille,
Norbert Frey,
Oliver Müller,
Elizabeth J. Cartwright,
Jonathan Chernoff,
Xin Wang,
Wei Liu
Publication year - 2019
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.118.312829
Subject(s) - unfolded protein response , endoplasmic reticulum , tunicamycin , tauroursodeoxycholic acid , microbiology and biotechnology , kinase , protein kinase a , chemical chaperone , xbp1 , biology , pressure overload , biochemistry , endocrinology , muscle hypertrophy , rna , cardiac hypertrophy , rna splicing , gene
Secreted and membrane-bound proteins, which account for 1/3 of all proteins, play critical roles in heart health and disease. The endoplasmic reticulum (ER) is the site for synthesis, folding, and quality control of these proteins. Loss of ER homeostasis and function underlies the pathogenesis of many forms of heart disease.