Open AccessCase report and immunohistochemical study of a malignant peripheral nerve sheath tumor in a dog
Author(s) -
Thaís de Almeida Moreira,
Leandro Willian Borges,
Talita Lopes Serra,
Diego Petrocino Caetano,
Marcelo Carrijo da Costa,
Alessandra Aparecida Medeiros-Ronchi
Publication year - 2017
Publication title -
brazilian journal of veterinary research and animal science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.187
H-Index - 17
eISSN - 1678-4456
pISSN - 1413-9596
DOI - 10.11606/issn.1678-4456.bjvras.2017.132447
Subject(s) - malignant peripheral nerve sheath tumor , vimentin , immunohistochemistry , pathology , neurofibroma , medicine , nerve sheath neoplasm , sarcoma , neoplasm , neurofibromatosis
Malignant peripheral nerve sheath tumor is rare and rarely reported in dogs. The term neurofibroma/sarcoma is classically used when the tumor is composed of Schawann and perineural cells. This work describes the clinical, histopathological, and immunohistochemical case of a subcutaneous malignant peripheral nerve sheath tumor, most likely a malignant neurofibroma located in the pelvic member of a Rottweiler dog. Histopathological features and immunohistochemical analysis corroborated the diagnosis, showing positivity for S-100 protein, vimentin, and CD57, and was useful to distinguish this type of neoplasm from other malignancies of similar morphologies.