Open AccessNasal oral fistula revealing Langerhans' cell histiocytosis in adult patient: case report
Author(s) -
A. Mzabi,
M. Thabet,
Taghrid Tlili,
Hend Zorgati,
J. Anoun,
I. Ben Hassine,
Monia Karmeni,
F. Ben Fredj,
Moncef Mokni,
C. Laouani
Publication year - 2021
Publication title -
the pan african medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.287
H-Index - 30
ISSN - 1937-8688
DOI - 10.11604/pamj.2021.40.16.27074
Subject(s) - medicine , langerhans cell histiocytosis , histiocyte , histiocytosis , nasal cavity , lesion , pathology , rare disease , lymph node , chemotherapy , fistula , surgery , disease
Langerhans cell histiocytosis (LCH) is a rare systemic disease caused by proliferation of mature histiocytes; its association to histiocyto fibroma is rarely reported. It rarely affects adults. We report a case of systemic LCH, in an adult patient with osteolytic lesion causing a fistula between the left nasal cavity and hard palate, involving the bone, lung, lymph node and associated to multiple histiocyto fibroma. The patient was operating for a fistula, and he was treated by chemotherapy and corticosteroids. Langerhans´ cell histiocytosis is a rare case, especially in adult patient. The diagnosis was based on histological and immunohistochemical analyses. This patient was treated by steroids and chemotherapy.