Open AccessCold agglutinins revelated by abnormalities to the cell blood count
Author(s) -
Hafid Zahid,
Rachid Hadef,
Fayçal Labrini,
Anass Yahyaoui,
N. Messaoudi
Publication year - 2021
Publication title -
the pan african medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.287
H-Index - 30
ISSN - 1937-8688
DOI - 10.11604/pamj.2021.38.328.9100
Subject(s) - cold agglutinin , medicine , hemagglutination , antibody , immunology , cold agglutinin disease , common cold , agglutination (biology) , abo blood group system , hemagglutinin (influenza) , autoantibody
Cold agglutinin are erythrocyte antibodies which possess the property of agglutinating red blood cells at temperatures of below 37°C, this phenomenon is reversible after heating. This is usually immunoglobulin M (IgM) class. Their pathogenicity is much more related to their temperature range of activity than their title. As we report in this observation, cold hemagglutination makes it difficult to interpret certain immunological tests such as ABO Rh blood grouping or searching for irregular antibodies (SAI). The discovery of cold agglutinins can be fortuitous revealing itself by disturbances and aberrations in the results of blood count or as part of a suggestive clinical or laboratory table cold hemagglutinin disease. The search for a lymphoid hematological at their diagnosis should be systematic.