Open AccessThe role of hypoxia and proton mechanism of parietal cells in the occurence of stress-induced and peptic ulcers
Author(s) -
Ya. I. Honskyi,
V. V. Hnativ,
B. О. Pereviznyk,
С. Р. Підручна,
І. P. Kuzmak,
Т. Ya. Yaroshenko
Publication year - 2017
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2016.v0.i4.7285
Subject(s) - duodenum , hypoxia (environmental) , stomach , peptic , mitochondrion , peptic ulcer , medicine , chemistry , oxygen , pathology , gastroenterology , biochemistry , organic chemistry
Based on experimental and clinical research, the authors revealed the preventive and therapeutic effect of continued intragastric delivery of molecular oxygen in case of stress-induced and peptic erosions and ulcers of stomach and duodenum. The hypothesis of possible role of hypoxia in the mechanism of injury of parietal cells is based on a consequence of transfer of protons from matrix of mitochondria and its further accumulation in cytoplasm. In this situation, the H+-dependent processes occur, particularly ATP synthesis and production of hydrochloric acid for which the protons are used.