Open AccessActivity of glutathione-dependent enzymes in spermatozoa in patients with pathospermia
Author(s) -
О. K. Оnufrovych,
Р. В. Фафула,
Io. A. Nakonechnyi,
Д. З. Воробец,
У. П. Єфремова,
З. Д. Воробец
Publication year - 2017
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2016.v0.i4.7246
Subject(s) - glutathione reductase , glutathione , glutathione peroxidase , antioxidant , sperm , peroxidase , andrology , gpx6 , gpx4 , enzyme , fertility , reductase , gpx3 , chemistry , biology , medicine , biochemistry , endocrinology , population , environmental health
The results of glutathione peroxidase and glutathione reductase activity in spermatozoa of patients with different forms pathospermia are presented in the paper. It was shown that glutathione peroxidase and glutathione reductase activity in sperm cells of patients is reduced in comparison with healthy men with preserved fertility. However, the most expressed changes in the activity of glutathione peroxidase and glutathione reductase are in spermatozoa of infertile men with associated forms patospermia and leucospermia. These changes indicate exhaustion of compensatory mechanisms of glutathione antioxidant system in the sperm cells of infertile men with pahospermia.